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These differences, which could arise from varied scavenging potentials toward different reactive metabolic by-products, suggests that aminoglycoside and fluoroquinolone-induced cytoplasmic condensation, lysis, and cell death may not be explained by the accumulation of peroxynitrite alone

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Consequently, CAR T cells are frequently directed towards tumor-associated antigens (TAAs) that, despite being overexpressed in tumors, may also be found in healthy organs and tissues, posing the risk of severe or even fatal adverse effects (Albert et al., 2017)